Hormonal Acne as an Adult
By Kyleen Davis, FNP
Let’s get one thing straight—acne isn’t just a teenage thing. Even though Hollywood would have us believe that breakouts magically disappear with high school, many women continue to deal with acne well into adulthood. And let’s be honest, it’s frustrating. It can feel like your skin is going backwards.
The culprit? Often, it’s hormones.
Hormonal acne is super common, especially for women, and it’s usually tied to shifts in hormones related to things like your menstrual cycle, perimenopause, or menopause. These changes can ramp up oil production and inflammation, leading to—you guessed it—breakouts.
You’ve probably tried the usual go-to treatments like benzoyl peroxide or retinoids. And yes, they can work! But if your acne isn’t budging, there are newer, evidence-backed options worth considering.
Let’s walk through them:
Spironolactone
Spironolactone wasn’t originally made for acne—it’s actually a blood pressure medication. But it turns out it has anti-androgen properties, which means it helps block certain hormones that trigger acne.
Many women have seen big improvements (we’re talking 50% to 100% better).1 Side effects are usually mild—think dizziness, headaches, or changes in your period. Most young, healthy women don’t need frequent blood work monitoring on this medication, but if you’re older or have other health concerns, your provider may want to monitor your potassium and kidney function. It’s not safe during pregnancy and isn’t used in men.
Chemical Peels
Chemical peels aren’t just for glowing skin—they can actually help clear up acne. They exfoliate dead skin cells, unclog pores, calm inflammation, and even regulate oil production.
We offer an Acne Salicylic Wash Peel that specifically targets breakouts, reducing redness, swelling, and excess oil.
Niacinamide
You might’ve seen this ingredient pop up in serums and moisturizers—and for good reason. Niacinamide (a form of vitamin B3) helps reduce oil production, calms inflammation, strengthens the skin barrier, and even fights off free radicals that can worsen acne.
It’s gentle, effective, and works for most skin types.
Clascoterone: A Topical Anti-Androgen
This one’s relatively new and exciting. Clascoterone (brand name Winlevi) is a cream that works like a topical version of spironolactone—it blocks hormone receptors in your skin, helping to reduce oil and inflammation.
The best part? It’s topical, so you skip the systemic side effects of oral medications. It’s safe for both women and men, even teens 12 and up. The downside? It’s still pretty new, so cost and insurance coverage might be a hurdle for some.
Combined Oral Contraceptives
Certain birth control pills can also double as an acne treatment, especially if your breakouts seem to follow your menstrual cycle. They help regulate hormones that contribute to acne, and some even come with added benefits for women dealing with cycle irregularities.
Some types seem to work better for acne than others. Pills containing drospirenone or other low-androgenic progestins often show the best results.2
Light & Laser Therapy: A Non-Invasive Option
If you’d prefer to stay away from pills and creams, light therapy might be a good fit.
Red light therapy reduces inflammation, speeds up healing, and even helps fade post-acne marks. Blue light therapy, on the other hand, targets acne-causing bacteria directly and is a great option if you’re coming off antibiotics or want a non-drug approach.
We offer in-office blue light treatments, and while at-home devices are out there, they tend to be less powerful.
Quick breakdown:
Red Light:
- Soothes inflammation
- Boosts collagen
- Helps with overall skin healing
Blue Light
- Zaps acne-causing bacteria
- Can help with precancerous skin issues too
- Promotes smoother, clearer skin over time
What’s Next? New and Emerging Options
Researchers are working on even more targeted hormonal treatments, like selective androgen receptor modulators (SARMs). The field is moving toward more personalized approaches, combining both topical and systemic therapies to get the best results.
The Bottom Line
Dealing with hormonal acne as an adult isn’t just common—it’s totally normal. And thankfully, treatment options are getting better and more tailored every year.
If you’re feeling stuck with your current routine, let’s talk. There are plenty of new solutions out there, and we’re here to help you find what works best for your skin. Book a consultation and let’s get you on the path to clearer, more confident skin.
Resources
- American Academy of Dermatology. (2025). Stubborn acne? Hormonal therapy may help.https://www.aad.org/public/diseases/acne/derm-treat/hormonal-therapy.
- Arrington, E. A., Patel, N. S., Gerancher, K., & Feldman, S. R. (2012). Combined oral contraceptives for the treatment of acne: A practical guide.Cutis, 90(2), 83–90.https://cdn.mdedge.com/files/s3fs-public/Document/September-2017/090020083.pdf
- Casey, F. E. (2023, January 11).Contraception and its impact on acne. Contemporary OB/GYN. https://www.contemporaryobgyn.net/view/contraception-acne
- Charny, J., Choi, J. & James, W. (2017). Spironolactone for the treatment of acne in women, a retrospective study of 110 patients. International Journal of Women’s Dermatology, 13, 3(2), 111-115.
- Cleveland Clinic. (2024, September 19).Red light therapy: Benefits, side effects & uses.https://my.clevelandclinic.org/health/articles/22114-red-light-therapy
- Fioravanti, G., & Casale, S. (2021). Social media and body dissatisfaction in young adults: An experimental investigation of the effects of different image content and influencing constructs.Body Image, 38, 1–11.https://doi.org/10.1080/14656566.2021.1918100
- Hebebrand, M., & Del Rosso, J. Q. (2025, January 28).What’s new in the medicine chest: Acne vulgaris.Dermatology Times. https://www.dermatologytimes.com/view/what-s-new-in-the-medicine-cabinet-acne-vulgaris
- Hebert, A., Thiboutot, D., Stein Gold, L., Cartwright, M., Gerloni, M., Fragasso, E., & Mazzetti, A. (2020). Efficacy and safety of topical clascoterone cream, 1%, for treatment in patients with facial acne: Two phase 3 randomized clinical trials.JAMA Dermatology, 156(6), 621–630.https://doi.org/10.1001/jamadermatol.2020.0465
- Lortscher, D., Admani, S., Satur, N., Eichenfield, L. Hormonal contraceptives and acne: a retrospective analysis of 2147 patients. Journal of Drugs in Dermatology, 15(6), 670-674.
- Macy, E., McCormick, T. A., Adams, J. L., Crawford, W. W., Nguyen, M. T., Hoang, L., Eng, V., Davis, A. C., & McGlynn, E. A. (2022). Association between removal of a warning against cephalosporin use in patients with penicillin allergy and antibiotic prescribing.JAMA, 327(3), 239–247.https://doi.org/10.1001/jama.2021.24751
- Miller, K. D., Siegel, R. L., Lin, C. C., Mariotto, A. B., Kramer, J. L., Rowland, J. H., & Jemal, A. (2019). Discrepancy between perceived diet quality and actual diet quality among US adult cancer survivors.JAMA Oncology, 5(6), 845–847.https://doi.org/10.1001/jamaoncol.2019.0601
- Paller, A. S., Mendes-Bastos, P., Siegfried, E. C., Raymundo, A. F., Yang, H., Hu, X., Calimlim, B. M., Platt, M., Zheng, Y., Teixeira, H., Liu, J., & Eyerich, K. (2024). Upadacitinib in adolescents with moderate to severe atopic dermatitis: Analysis of 3 phase 3 randomized clinical trials through 76 weeks.JAMA Dermatology, 160(12), 1304–1313.https://doi.org/10.1001/jamadermatol.2024.3696


















