Can a DNA Test Tell What Skincare You Need?
by Dr. Koji Ota
There has been an increase in the availability and popularity of DNA tests aimed to provide personalized insight into one’s health, including one’s skin. This post is an introduction to what a DNA test can and cannot tell you about your skin and how you can incorporate information obtained from these tests to help you build a personalized skincare routine.
DNA Results
A DNA test can reveal insights into some genetic predispositions that may influence your skin. For instance, variants in the filaggrin (FLG) gene can indicate skin barrier dysfunction that leads to more eczema-prone skin. MC1R variants affect skin and hair pigmentation, which affects UV sensitivity and even skin cancer risks. DNA tests can also test for genes thought to play a role in skin aging, skin structure, and antioxidant defenses, providing some insight into an individual’s skin characteristics.
However, information obtained from a genetic test alone is not enough to determine a person’s skincare needs. It does not take into account other factors which can be just as, if not more important, than information obtained from a genetic test.
Other Factors to Consider
External factors such as the environment (UV, humidity) or behavior (smoking, topical regimens) greatly impact your skin. For example, people who live in a dry, cold climate will need to focus on maintaining a healthy skin barrier through proper moisturization. There are many factors that play a role in various skin conditions, such as the skin microbiome in acne and rosacea.
Additionally, DNA tests offer skin care suggestions with limited regulation and clinical validation. A recent study showed that genetic tests may lead to high false positive rates, as well as misclassification of common benign genetic variants as “high risk.”
So how can you incorporate these DNA tests into your skin care regimen?
One can use these tests as a data point: if you have an MC1R gene variant that conveys a higher risk of UV damage, you may want to prioritize sun protection.
However, genetic testing is not meant to be a standalone guideline. A true personalized skin care routine will take your lifestyle and environment into account. A board-certified dermatologist can incorporate all these data points to help you come up with a safe and effective skincare routine.
References
Palmer CNA, Irvine AD, Terron-Kwiatkowski A, et al. Common loss-of-function variants of the epidermal barrier protein filaggrin are a major predisposing factor for atopic dermatitis. Nat Genet. 2006;38(4):441–446. doi:10.1038/ng1767
Sturm RA. Molecular genetics of human pigmentation diversity. Hum Mol Genet. 2009;18(R1):R9–R17. doi:10.1093/hmg/ddp006 (discussion of MC1R and UV sensitivity/pigmentation)
Rittié L, Fisher GJ. UV-light-induced signal cascades and skin aging. Ageing Res Rev. 2002;1(4):705–720. doi:10.1016/S1568-1637(02)00045-6 (collagen, MMPs, photoaging)
Briganti S, Picardo M. Antioxidant activity, lipid peroxidation and skin diseases. What’s new. J Eur Acad Dermatol Venereol. 2003;17(6):663–669. doi:10.1046/j.1468-3083.2003.00867.x (oxidative stress, antioxidant defense genes)
Grice EA, Segre JA. The skin microbiome. Nat Rev Microbiol. 2011;9(4):244–253. doi:10.1038/nrmicro2537 (role of microbiome in acne, barrier/skin health)
Manolio TA, Collins FS, Cox NJ, et al. Finding the missing heritability of complex diseases. Nature. 2009;461(7265):747–753. doi:10.1038/nature08494 (small effect sizes of common variants; relevance to polygenic traits)
Duffy DC, Ritchie H, Beecham R. Direct-to-consumer genetic testing: a systematic review of health-related information accuracy and implications. J Med Genet. 2018;55(9):610–616. doi:10.1136/jmedgenet-2017-104740 (limitations and variable clinical validity of DTC tests)
Ethical concerns of direct-to-consumer genetic testing. Ferreira, Alana et al. Journal of the American Academy of Dermatology, Volume 90, Issue 5, 1117 – 1118












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