By Kyleen Davis

If you are like many of our patients, you probably read the New York Times. Chances are that you or someone you know came across a recent article about a new and inexpensive treatment that can help grow your hair back. This article, entitled, An Old Medicine Grows New Hair for Pennies a Day, was published in the late summer of last year and quickly began trending. Many of you have brought up this article during your office visits to discuss hair loss.  Others may be curious about the validity of these claims. What are these new therapies? And do they actually work?

About Hair Loss

Unfortunately, hair loss is an extremely common condition, affecting an estimated 50 million men and 30 million women in the United States. The American Academy of Dermatology reports that over half of men will have moderate to severe hair loss by the age of 50. Similarly, more than 50% of women will develop some form of female pattern hair loss by age 79.

Treatments for Hair Loss

The good news is that there are many treatment options available for patients who are struggling with hair loss. Determining the type of hair loss is crucial to tailor the treatment plan to the patient’s specific needs. In dermatology, we can diagnose the type of patient hair loss with a careful history, physical examination, and close-up inspection of the hair follicles, a process known as trichoscopy. Lab work or scalp biopsy may also be ordered to confirm the diagnosis. While multiple types of hair loss, or alopecia, exist, androgenetic alopecia (male and female pattern hair loss) is the most common cause of hair loss in the United States.

Androgenetic alopecia (AGA) has traditionally been treated with topical minoxidil (Rogaine) since the Food and Drug Administration (FDA) approved the 5% solution for men in 1988 and the 2% solution for women in 1991. Prior to its approval, minoxidil’s side effect of hypertrichosis (excessive hair growth) was found incidentally when patients taking this medication at doses of 10-40 mg daily for high blood pressure started to grow more hair. For many years the oral form of minoxidil was avoided as a therapeutic option for hair loss due to potential adverse effects and because topical minoxidil was effective.

New Type of Hair Loss Treatment

That is, until recently when an Australian physician named Dr. Rodney Sinclair conducted a study showing that a fraction of the standard dose of minoxidil could help grow hair with less risk of side effects. Since that time, multiple studies have been conducted on the use of oral minoxidil in the treatment of hair loss. Most studies have demonstrated that low-dose oral minoxidil (LDOM) at doses ranging from 0.25 mg to 2.5 mg per day was generally safe and highly efficacious for the treatment of alopecia, especially for AGA. While a significant portion of patients taking LDOM developed hair growth of the sides of the face and temples, this did not typically result in discontinuation of the medication.

There are several treatments for androgenetic alopecia, including other oral agents, topical therapy, platelet rich plasma (PRP), low level laser therapy, and vitamin supplements. Many of them work well together and each has a specific risk benefit profile that should be considered for an individual patient. The great news is that thinning hair can be improved!

References

American Academy of Dermatology. (2022). What is male pattern hair loss, and can it be treated? Available online at: https://www.aad.org/public/diseases/hair-loss/treatment/male-pattern-hair-loss-treatment.

Beach, R., McDonald, K., & Barrett, B. (2021). Low-dose oral minoxidil for treating alopecia: A 3-year North American retrospective case series. Journal of the American Academy of Dermatology, 84(3), 761-763.

Fabbrocini, G., Cantelli, M., Masara, A., Annunziata, M., Marasca, C., & Cacciapuoti, S. (2018). Female pattern hair loss: A clinical, pathophysiologic, and therapeutic review. International Journal of Women’s Dermatology, 4(4), 203-211.

Heymann, W. (2022). Coming full circle (almost): low dose oral minoxidil for alopecia. American Academy of Dermatology, Dermatology World Insights and Inquiries, 4(1). Available online at: https://www.aad.org/dw/dw-insights-and-inquiries/archive/2022/low-dose-oral-minoxidil-alopecia.

Jimenez-Cauhe, J., Saceda-Corralo, D., Rodrigues-Barata, R., Moreno-Arrones, O., Ortega-Quijano, D., Fernandez-Nieto, D., Jaen-Olasalo, P., & Vano-Galven, S. (2020). Safety of low-dose oral minoxidil treatment for hair loss. A systematic review and pooled-analysis of individual patient data. Journal of Dermatology Research and Therapy, 33(6), e14106.

Kolata, G. (2022). An old medicine grows new hair for pennies a day, doctors say. The New York Times. Available online at: https://www.nytimes.com/2022/08/18/health/minoxidil-hair-loss-pills.html.

Pfizer (Pharmacia & Upjohn Company). (2015). Loniten ™ minoxidil tablets, USP, package insert. Available online at: https://www.accessdata.fda.gov/drugsatfda_docs/label/2015/018154s026lbl.pdf.

Rajab, F. (2022). Low-dose oral minoxidil for hair growth. Dermatology Times, 43(11).

Ramos, P., Sinclair, R., Kasprzak, M., & Miot, H. (2020). Minoxidil 1 mg oral versus minoxidil 5% topical solution for the treatment of female pattern hair loss: A randomized clinical trial. Journal of the American Academy of Dermatology, 82(1), 252-253.

Randolph, M. & Tosti, A. (2021). Oral minoxidil treatment for hair loss: A review of efficacy and safety. Journal of the American Academy of Dermatology, 84(3), 737-746.

Rhodes, T., Girman, C., Savin, R., Kaufman, K., Guo, S., Lilly, F., Siervogel, R., & Chumlea, W. (1998). Prevalence of male pattern hair loss in 18-49 year-old men. Dermatologic Surgery, 24(12), 1330-1332.

Sharma, A., Michelle, L., Juhasz, M., Ramos, P., Mesinkovska, N. (2020). Low dose oral minoxidil as treatment for non-scarring alopecia: a systematic review. International Journal of Dermatology, 59(8), 1013-1019.

Sinclair, R. (2018). Female pattern hair loss: A pilot study investigating combination therapy with low-dose oral minoxidil and spironolactone. International Journal of Dermatology, 57(suppl 65). Available online at: https://www.researchgate.net/profile/Rodney-Sinclair/publication/321756113_Female_pattern_hair_loss_A_pilot_study_investigating_combination_therapy_with_low-dose_oral_minoxidil_and_spironolactone/links/5a81583fa6fdcc0d4bacaa59/Female-pattern-hair-loss-A-pilot-study-investigating-combination-therapy-with-low-dose-oral-minoxidil-and-spironolactone.pdf?origin=publication_detail.

By Kyleen Davis, FNP

Androgenetic alopecia (AGA) is the medical term used to describe a type of hormone-related hair loss that occurs in genetically-susceptible men and women. It is extremely common, affecting approximately 50 million men and 30 million women in the United States. Androgenetic alopecia can be significantly distressing to affected individuals and seriously impact their quality of life. Fortunately, multiple treatment strategies have been shown to help.

The onset of AGA is typically between the ages of 20 to 40 years old, but can start as early as a person’s teens. The risk of developing this condition increases later in life. Men are more commonly affected than women and may present in different ways. In males, recession of the frontal hairline is noted early on, followed by a gradual thinning at the temples and crown, forming an “M” shape. In females, the frontal hairline is preserved with a generalized thinning of the hair and widening of the part. AGA rarely leads to complete baldness in women. Other common features of AGA include gradual onset of hair loss, increased hair shedding, and a transition from large, thick, pigmented hairs to thin, short, wispy hairs.

Nhtindia / CC BY-SA

Diagnosing Androgenetic Alopecia

Patients with suspected AGA should be evaluated by an experienced dermatologic provider. A careful medical history and physical examination of the hair, scalp, and nails should be obtained, along with laboratory testing to rule out underlying diseases or vitamin deficiencies. A biopsy of the scalp is occasionally necessary to differentiate AGA from other types of alopecia.

Treatment of Androgenetic Alopecia

Once a diagnosis of AGA is established, treatment may be initiated with one of the following medications:

• Minoxidil:
  • Available in 2% or 5%, topical minoxidil is the most commonly recommended treatment for AGA. Patients need to use this medication continuously for one year before determining if it will work for them. At the beginning of treatment, individuals may notice a temporary increase in hair loss, which stops as the hair begins to regrow. Common side effects include dryness, scaling, and/or itching of the scalp. Occasionally, excessive hair growth in unwanted places, like the cheeks or forehead, may occur as a result of taking this medication.
• Prescription medications:
  • Finasteride is an FDA-approved medication used to treat AGA in men. It has been shown to halt the progression of hair loss while also leading to regrowth of hair in many cases. A commonly reported side effect is sexual dysfunction, which is reversible once the medication is stopped.
  • Spironolactone is often used in women with female-pattern hair loss. This medication acts to suppress the effects of certain hormones, and can be particularly useful in polycystic ovarian syndrome (PCOS) and hirsutism—defined as excessive hair growth on the body.
• Vitamins:
  • Many supplements containing biotin, folic acid, and antioxidants have helped patients with thinning hair.  It is important to mention any supplements you are taking to your physician prior to laboratory testing as they may affect results.
• Shampoos:
  • One prescription shampoo, ketoconazole, has been shown to increase hair thickness in several studies. In addition, other over-the-counter shampoos can help hair hold moisture, making it appear thicker and fuller, as well as reduce breakage.
• Laser therapy:
  • The FDA has approved low-level laser devices to treat hair loss at home. These lasers emit a low level of light that has been shown to help grow hair in a limited number of studies.
• Platelet-rich plasma therapy:
  • Platelet-rich plasma therapy (PRP) uses a person’s own blood to stimulate cells to grow hair. After the blood is drawn, it is spun down in a machine, separating it into different components. The plasma is then injected into the scalp. PRP therapy is a relatively new therapy with studies currently underway to help determine its safety and efficacy.

If you suspect you have AGA, it is important you see your dermatologist as soon as possible to discuss the treatment options that are best for you. Treatment works best when started at the first sign of hair loss.

Shop hair care products now on our online shop.

References:

• American Academy of Dermatology. Thinning hair and hair loss: could it be female pattern hair loss? Available at: https://www.aad.org/public/diseases/hair-loss/types/female-pattern. Accessed May 23, 2020.
• Feinstein, R. (2020). Androgenetic alopecia. Medscape. Available online at: https://emedicine.medscape.com/article/1070167-overview#a4. Accessed May 23, 2020.
• Harvard Women’s Health Watch. (November 2018). Treating female pattern hair loss. Harvard Health Publishing: Harvard Medical School. Available online at: https://www.health.harvard.edu/staying-healthy/treating-female-pattern-hair-loss. Accessed May 23, 2020.
• Gan, D. & Sinclair, R. (2005). Prevalence of male and female pattern hair loss in Maryborough. Journal of Investigative Dermatology Symposium Proceedings, 10, 184-189.